Abstract Background Intraoperative tranexamic acid is used increasingly during implant-based breast reconstruction to reduce hematoma and seroma formation. However, evidence supporting the effectiveness of tranexamic acid in this setting remains limited. Objectives This study aims to compare the risk of hematoma and seroma in patients treated with and without intraoperative intravenous tranexamic acid during implant-based breast reconstruction. Methods Medical records of patients who underwent breast reconstruction at three plastic surgical departments between 2010 and 2023 were retrospectively reviewed. We compared the risk of hematoma and seroma between patients treated with and without intraoperative intravenous tranexamic acid using Robust Multivariable Cox regression with inverse probability of treatment weighting. Results We included 1782 patients who underwent implant-based breast reconstruction, of whom 352 received intraoperative intravenous tranexamic acid. Multivariable analysis showed a non-significant reduction in the risk of hematoma (HR 0.81; p=0.51) and seroma (HR 0.88; p=0.68) in patients who received tranexamic acid. Furthermore, the time to hematoma was significantly longer (2 vs. 1 day, p=0.03), as well as the time to drain removal (7 vs. 6 days, p0.001) for patients treated with tranexamic acid. However, the time to discharge was significantly shorter (4 vs. 5 days, p0.001). Conclusions Intraoperative administration of tranexamic acid was associated with a non-significant reduction in the risk of hematoma and seroma, suggesting a limited clinical effect in patients undergoing implant-based breast reconstruction. However, future studies are needed to definitively determine the effects in implant-based breast reconstruction.
Norlin et al. (Sun,) studied this question.