Bioactive potential of Justicia acuminatissima: a review of antioxidant, antimicrobial, and anti-inflammatory activities

Justicia acuminatissima, a species of the Acanthaceae family, is widely distributed in the Amazon and traditionally used in the treatment of various diseases. This review aimed to analyze its bioactive potential, with a focus on antioxidant, antimicrobial, and anti-inflammatory activities. A total of 14 scientific publications from the last decade were selected through searches on Google Scholar and SciELO, based on criteria such as methodological relevance and direct association with the species. The studies revealed the presence of bioactive compounds such as flavonoids (notably luteolin derivatives), terpenes (including triterpenes like lupeol), and tannins. These metabolites contribute to the neutralization of free radicals, inhibition of pathogenic microorganisms, and modulation of inflammatory responses. Although specific research on the antioxidant effects of the species remains limited, existing evidence supports its therapeutic relevance. The findings reinforce the potential of J. acuminatissima as a natural source for phytotherapeutic development and highlight the importance of continued scientific investigation, especially in the Alto Solimões region of Amazonas, where biodiversity holds great promise for biotechnological innovation.