August 16, 2025

Effects of Punarnavadi Kwath and Navaka Guggulu in Medoroga (Obesity) – An Open-label Randomized Controlled Trial

Key Points

Participants who received punarnavadi kwath showed significant reduction in body weight and BMI, enhancing health outcomes.
The trial reported improvements in waist circumference and hip circumference, crucial for obesity management.
Assessment involved measuring changes in lipid profile and subjective symptoms related to medoroga over 30 days.
Results indicate that punarnavadi kwath may be effective in managing obesity symptoms, supporting traditional medicine approaches.

Abstract

A BSTRACT Background: In Ayurveda , the lifestyle disorders are placed under the umbrella of Medoroga . Nowadays, Medoroga has become a global epidemic and alarming condition for the scientific health community. It is defined as Shleshma Nanatmaja Vyadhi, Medo Vriddhi Vikara, Santarpanjanya Vyadhi , and Atibrumhan-nimitaja Vyadhi . The etiopathogenesis, prognosis, and management of obesity are closely related with Medoroga in Ayurveda. Navaka Guggulu and Punarnavadi Kwath are mentioned in the literature for the management of Medoroga (obesity). Aim: This trial aims to determine the efficacy of Punarnavadi Kwath and Navaka Guggulu in the management of Medoroga (obesity). Materials and Methods: A randomized, controlled, open-label, single-centered clinical trial was conducted on 80 patients of Medoroga (obesity). Patients aged 21–60 years having clinical characteristics resembling Medoroga as outlined in the classical texts (short or repeated breathing, foul odor of the body, decreased vitality, excessive thirst etc.) and body mass index (BMI) ranging from 30.0 to 40 kg/m 2 were included. In Group A oral administration of Navaka Guggulu 2 tablets twice a day each of 500 mg (2 g daily), and in Group B- Punarnavadi Kwath , 40 mL twice daily were given for 30 days’ duration. The assessment was done based on the improvement in body weight, BMI, waist circumference, hip circumference, waist-hip ratio (WHR), lipid profile, and relief in sign and symptoms of Medoroga . Results: The significant results were seen in body weight and BMI, hip circumference, waist circumference, serum cholesterol, and some of the subjective parameters such as Alasya, Daurgandhya, Kshudra Swash, Daurbalya, Swapna, Ati-kshuda, Snigdhangta , and significant result was seen in WHR, Swedaadhikya, Atipipasa, Krathan, Alpamaithun in the trial Group B compare to Group A. Conclusion: The study found an overall improvement in the signs and symptoms of Medoroga (obesity) in the participants who had received Punarnavadi Kwath , demonstrating its potential in managing this disease.

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