Background: Inflammation is involved in pathogenesis of many diseases. Antiinflammatory chemicals can be used to treat such illness,especially if they are derived from plant sources as they will have fewer side effects. Objective:to find out the outcome of ethanolic extract of syzygium aromaticum flower buds on markers of inflammation in albino rats.Material and method: Antiinflammatory activity was investigated in albino rats using a experimental model of inflammation, the “formalin test” (injecting 5 % formalin into subplantar surface of right hind paw). Ninety rats were uniformly divided into three groups designates as control A,experimental B and refrence C. Intraperitoneal injection of normal saline, syzygium aromaticum flower bud extract and indomethacin was used. In these rats, foot edema was measured by Vernier caliper. Blood sampling was done through cardiac punture under anaesthesia to determine total and differential leukocyte counts and serum tumor necrosis factor alpha (TNF-α) levels. Results: The clove extract produced significant (p=0.00) decrease in inflammatory response initiated by 5% formalin. The extract significantly decreased (p=0.009) serum TNF-α. However, its effect on the total and differential leukocyte counts was non-significant (p˃0.05).Conclusion: The ethanolic extract of syzygium aromaticum possesses potent anti-inflammatory effects.
Tabassum et al. (Sat,) studied this question.