Supplemental Figure S4 from Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5 | Synapse
August 17, 2025
Supplemental Figure S4 from Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5
Key Points
Collagen XVII plays a significant role in promoting tumor growth in pancreatic ductal adenocarcinoma by influencing PIK3R5 levels, enhancing cancer progression.
Active AKT levels were notably reduced in cells lacking collagen XVII, highlighting the gene's role in cancer cell signaling and survival.
Observational analysis of gene expression revealed notable changes in response to collagen XVII deficiency, impacting tumor behavior.
These findings suggest that targeting collagen XVII may offer new therapeutic avenues in managing pancreatic ductal adenocarcinoma.
Abstract
Changes in gene expression and active AKT levels in collagen XVII-deficient cells