Azadirachta indica and Calotropis procera are medicinal plants widely recognized for their therapeutic properties in traditional medicine. This study evaluated the antioxidant activity of leaf extracts from both species, using methanol and hexane solvents through the maceration technique. The antioxidant potential was assessed using the DPPH (2,2-diphenyl1-picrylhydrazyl) free radical scavenging assay. Phytochemical screening revealed the presence of several bioactive compounds, including saponins, alkaloids, flavonoids, tannins, phenols, and glycosides. Among the extracts, the methanolic extract of A. indica demonstrated the highest antioxidant activity, with 76.10% inhibition, followed by the methanolic extract of C. procera, with 73.42% inhibition. Quantitative phytochemical analysis showed that A. indica contained higher concentrations of phenols (2.591%), tannins (3.595%), and glycosides (65%), while C. procera had elevated levels of saponins (14.40%), alkaloids (1.368%), and glycosides (35%). These findings indicate that Azadirachta indica and Calotropis procera possess significant antioxidant activity, suggesting their potential as sources of natural antioxidant agents. The abundance of bioactive compounds in these plants underscores their suitability for the development of therapeutic formulations targeting oxidative stress-related conditions. Further comprehensive research is recommended to isolate and characterize the specific compounds responsible for their antioxidant effects.
Labaran et al. (Thu,) studied this question.
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