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August 21, 2025Open Access

SOX9: an important factor in regulating breast cancer

YWYaru WangShandong University of Traditional Chinese Medicine JCJuhang ChuTongji University LHLuyao HuangShanghai Tenth People's Hospital

Key Points

Targeting sox9 may enhance the therapeutic effect in breast cancer, and improve patient outcomes with better treatment options.
Research shows that sox9 is involved in tumor initiation, proliferation, migration, and chemotherapy resistance in breast cancer.
The review focuses on the structure, function, and new developments regarding sox9 in the pathogenesis of breast cancer.
Future clinical strategies may involve targeting sox9 to improve treatment efficacy and provide better outcomes for patients.

Abstract

The SRY-Box Transcription Factor 9 (SOX9) is a crucial transcription factor that controls the growth, differentiation, and stemness of progenitor cells. According to research, SOX9 protein controls the initiation and progression of tumors by directly participating in tumor initiation, proliferation, migration, and chemotherapy resistance. Although SOX9 overexpression is frequently found in breast cancer, the precise molecular mechanism is yet unknown. This article reviews the structure, function, and new developments of SOX9 in the pathogenesis and treatment of breast cancer, and proposes that targeting SOX9 may improve the therapeutic effect of breast cancer and provide a reference for clinical work.

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