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August 22, 2025Indian Journal of Pharmacology0 citationsOpen Access

A case series of vildagliptin-associated bullous pemphigoid - Rare side effect

MSMohit Kumar Shahi JAJ V Ashwin ASAstha Singh

Key Points

Three patients with diabetes developed bullous pemphigoid after vildagliptin use, indicating a potential link.
Notable symptoms included fluid-filled blisters and skin erosions, highlighting serious adverse effects.
Case series analysis showed that bullous pemphigoid can appear following the use of vildagliptin in diabetes patients.
Awareness of possible side effects, such as bullous pemphigoid, is crucial for vildagliptin users.

Abstract

Vildagliptin, among the most commonly used, OHA, belongs to group dipeptidyl peptidase-4 inhibitors for managing type 2 diabetes mellitus, has recently been associated with bullous pemphigoid, characterized by fluid-filled blisters and erosions on the skin and mucous membranes. We report the series of three cases of bullous pemphigoid in patients of diabetes, who developed bullous pemphigoid after vildagliptin use.

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