Delivery strategies to improve the pharmacological efficacy of NRF2 modulators: A review

Key Points

• Enhancing pharmacological efficacy is critical in optimizing NRF2 modulator therapies, and various delivery strategies can achieve this.
• A focus on the NRF2/KEAP1 signaling pathway reveals its role in regulating gene expression of detoxifying enzymes crucial for cellular health.
• The review analyzes multiple delivery strategies aimed at improving the pharmacological efficacy of NRF2 modulators.
• This analysis highlights the need for innovative delivery methods to fully utilize NRF2 modulators' therapeutic potentials.