backgrounds: Amlodipine (calcium channel Blockers (CCBS)) drug is Dihydropyridines mostly selective for vascular smooth muscles and used in treatment of hypertensive patient who also have asthma, diabetes and peripheral vascular disease and used also in treatment of angina. There are about 52 brands of this Amlodipine 5 mg tablets including 8 domestic brands available in Yemeni drug market. Objectives: The study aimed to pharmacopeial evaluation of different brands of amlodipine 5mg tablet that available in Yemeni drug market. Methods: The quality specifications, of six Amlodipine 5 mg tablet brands available in Yemeni drug market including two domestic brands, were assessed in this study. Assessment included content assay, tablet weight variation, hardness, friability and disintegration. In addition, drug dissolution profile. Results: Although there were differences in results, all the tested brands complied pharmacopeial limits regarding most of the tests. Unfortunately, there are brands showed bad and not accepted results. Conclusions: The tested brands showed acceptable results for most tests, but there are also unacceptable results for some brands, such as brand-F.
Al-Ghani et al. (Tue,) studied this question.
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