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August 23, 2025Open Access

Assessment of PBC Pruritus From the ITCH‐E Study: Quality of Life, Productivity, and Treatment Experiences

Key Points

Patients with moderate/severe pruritus reported significantly worse health-related quality of life compared to those with mild/no pruritus.
The moderate/severe pruritus group experienced 57% activity impairment due to PBC versus 36% in the mild/no pruritus group.
Assessment included multiple questionnaires measuring itch severity and quality of life across 90 participants with PBC.
These findings underscore the urgent need for better treatments to alleviate pruritus in PBC patients.

Abstract

ABSTRACT Background p < 0.001). The MSP group had a lower employment rate (42%) than the NMP group (53%). Fewer than 25% of the MSP group were receiving itch treatment. Conclusions Individuals with PBC and pruritus report limited pruritus treatment use and minimal itch relief. Those with moderate/severe pruritus experience a greater HRQoL burden and reduced activity compared to those with mild/no pruritus. This highlights the need for effective treatments that ameliorate pruritus in patients with PBC.

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