Hyaluronic acid (HA), owing to its excellent biocompatibility, reversibility, and tunability, has become a widely used soft tissue filler in nonsurgical aesthetic medicine. With advances in cross-linking technologies and product diversification, its applications have expanded from superficial wrinkle correction to structural volumetric restoration and contour sculpting. Based on 120 consecutive cases treated at one institution between 2023 and 2024, this study analyzed the maintenance of efficacy in different facial regions, discrepancies between subjective and objective evaluations, and adverse reaction profiles. It further proposes a “site–layer–product–technique” matching framework and a “three-quick-one-transfer” emergency management strategy. Results showed that patient satisfaction peaked from immediately post-injection to three months, with region-specific decline observed after six months. Common adverse reactions were generally short-term and reversible, with no severe vascular events reported. Mechanistic analysis and follow-up strategies suggest that late-phase micro-touch-ups combined with interface reshaping may extend natural outcomes while minimizing risks.
Wei Liu (Sun,) studied this question.