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This is a Literature Review study.

August 23, 2025Open Access

Chelidonium majus L.: A Current Perspective on Isoquinoline Alkaloids, Emerging Phytochemicals, Alkaloid Biosynthesis, and Biological Activities

RRRamona Maria RomanuWest University of Timişoara SLSergio LigaPolytechnic University of Timişoara MTMaria Roberta TriponWest University of Timişoara

Key Points

Isoquinoline alkaloids in Chelidonium majus exhibit diverse biological activities, including anticancer and antioxidant effects.
The review identifies major research themes related to phytochemicals and biosynthetic pathways of these alkaloids.
Conducting a bibliometric analysis using the Scopus dataset helped pinpoint research trends over a decade.
Continued investigation is essential to improve the therapeutic potential of Chelidonium majus while ensuring safety.

Abstract

Phytochemistry serves as a vital bridge between traditional medicinal knowledge and modern scientific research, with important implications for pharmaceutical and industrial applications. This review offers an updated and integrated perspective on Chelidonium majus (greater celandine), focusing on its isoquinoline alkaloids—the principal bioactive constituents—alongside emerging phytochemicals (e.g., lignanamides, polyphenols). Detailed biosynthetic pathways of isoquinoline alkaloids are described, tracing their formation from the shikimate pathway to multiple structural subclasses. Reported biological activities include anticancer, antioxidant, anti-inflammatory, antimicrobial, antiviral, and immunomodulatory effects. A bibliometric analysis was conducted using VOSviewer software (Scopus dataset, 2015–2025), enabling the identification of major research themes and temporal trends. These research tools supported a structured and data-driven overview of the current scientific landscape. However, additional studies are needed to optimize its therapeutic use while ensuring efficacy and safety.

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