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August 25, 2025Open Access

Kerosene as a Potential Substitute for Xylene in Histopathology: A Prospective Comparative Study

Key Points

Kerosene alone had the poorest outcomes across histological parameters, while xylene consistently performed better.
Xylene showed the highest rates of good ribboning and section quality at 80%, with kerosene yielding up to 85% poor results.
This experimental study assessed 60 tissue samples across three groups: xylene, xylene–kerosene mix, and kerosene alone.
Findings suggest that, while xylene outperforms kerosene, the latter may be a cost-effective alternative with some benefits for diagnostic accuracy.

Abstract

Aims: We evaluated kerosene as a potential substitute, assessing its clearing efficiency, impact on tissue morphology, staining quality, and diagnostic accuracy. Study Design: A prospective comparative study. Place and Duration of Study: The Cross-sectional research was conducted at the Department of Pathology, Vinayaka Mission’s KirupanandaVariyar Medical College however, kerosene is a cost-effective and less toxic alternative with acceptable performance. While kerosene showed slightly lower efficiency, tissue morphology and diagnostic accuracy were maintained. A xylene–kerosene mixture offered improved outcomes over kerosene alone.

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Authors

Azhagan Muthu Paranjothi

Thamilselvi Ramachandran

Vinayaka Missions University

Jasma Priyanga Emmanuel

Journals

Journal of Pharmaceutical Research International

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Kerosene as a Potential Substitute for Xylene in Histopathology: A Prospective Comparative Study

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Abstract

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