Trifluoroborate-Appended Cyclen Complexes of Paramagnetic Transition Metals (Ni2+, Co2+) as Fast-Relaxing 19F MRI Probes

Key Points

• Trifluoroborate complexes improve sensitivity for 19 F MRI imaging, enhancing the detection of paramagnetic metals.
• The incorporation of BF 3 groups in cyclen ligands leads to successful complex formation with Ni 2+ and Co 2+ ions.
• Assessment of relaxation rates shows these complexes are effective as MRI probes in experimental models.
• These findings suggest that paramagnetic transition metals could be pivotal in developing advanced imaging techniques.