This research demonstrates enantioselective coupling of alkyl chains using photoredox and nickel catalysis, highlighting its application in synthesizing valuable molecules.
Key Points
This method achieves efficient enantioselective transformations of alkyl radicals, resulting in enantioenriched products.
The approach connects photoredox and nickel catalysis to control the selectivity of radical reactions, an advancement in organic synthesis.
A one-pot process includes generating N-hydroxyphthalimide in situ, simplifying the overall synthetic route for complex scaffolds.
Comprehensive mechanistic studies outline a Ni(I)/Ni(II) cycle integral to achieving controlled radical couplings.