Mucin 1 Antigen Mimetic Functionalized Mannosylated Peptide Nanofibers for Antigen Uptake and Immune Modulation

Key Points

• Immune modulation was successfully achieved with mannosylated peptide nanofibers, enhancing dendritic cell function.
• The study highlighted the significant role of mucin 1 in improving antigen uptake by dendritic cells.
• Observations from in vitro cell cultures and organ-on-chip models confirmed the efficacy of the peptide nanofibers.
• These findings suggest a promising strategy for vaccine development using peptide nanofibers to target dendritic cells.