Immunologic, molecular genetic features and prognosis in occupational asthma

Purpose. To study the clinical, immunological markers of the risk of developing occupational asthma (OA) under the influence of sensitizing substances. Material and methods. The study was attended by 170 patients with various OA phenotypes, the control group was 50 conditionally healthy people. External respiratory function, levels of intraleukins-1β, -4, -6, -8, -10, -17, tumor necrosis factor-α, vascular endothelial growth factor, monocyte chemotactic protein-1, interferon-γ, and total immunoglobulin E were studied in the study groups. Genotyping by polymerase chain reaction was also performed. Results. Features of clinical and immunological manifestations were established in allergic and non-allergic OA phenotypes, as well as phenotypes of the combined course of OA with a occupational chronic obstructive pulmonary disease and metabolic syndrome. Genetic risk markers of OA were revealed in the conditions of the effects of sensitizing substances (polymorphic variants of the RS1837253 TSLP gene). Conclusion. The identified clinical, immunological and genotypic features for various OA phenotypes, the installed profiles of OA genotypes can help in early diagnosis, prognosis, prevention and pharmacotherapy of OA.