The pharmaceutical manufacturing unit is a facility where staff and supplies can be used repeatedly to complete various activities. Results from environmental monitoring reveal details about the rooms physical arrangement, the operation of the HVAC system, gowning customs, employee hygiene, equipment, and cleaning procedures. Environmental monitoring is a key part of any pharmaceutical, biotechnology-produced, or medical device-controlled process to demonstrate that the microbial particulate level of all clean-room air and work surfaces is at acceptable levels. It is also regulation-driven. Microorganisms are used to classify particulate particle levels, microbial diversity, and ecosystem health.
Markam et al. (Tue,) studied this question.