Figure S5 from CRISPR Screens Identify POLB as a Synthetic Lethal Enhancer of PARP Inhibition Exclusively in BRCA-Mutated Tumors

Supplementary Figure S5. Body weight of the animals is not impacted by the treatment with niraparib – related to Figure 6. A) Effect on body weights of animals containing MDA-MB-436 sgIntron or sgPOLB xenografts treated with vehicle and niraparib at 15 mpk once daily for 28 days. Data is represented as % change in body weights until day 28. B) Effect on body weights of animals containing DLD-1 BRCA2 null sgIntron or sgPOLB xenografts treated with vehicle and niraparib at 30 mpk (left) and 60 mpk (right) once daily for 20 days. Data is represented as % change in body weights until day 20.