Abstract Background Recurrent embryo implantation failure (RIF) poses a considerable obstacle in the management of in vitro fertilization (IVF), as IVF failure has been linked to the presence of endometriosis, the growth of endometrial-like tissue outside the uterus. Therefore, this study aimed to reveal the molecular mechanisms connecting endometriosis and RIF, offering valuable knowledge on potential therapeutic targets and biomarkers. Methods A comprehensive investigation was conducted on gene expression data from the GEO database, focusing on three datasets related to endometriosis and RIF, which revealed distinct gene expression patterns and facilitated functional enrichment analysis to identify significant biological processes and molecular pathways associated with these differentially expressed genes. Protein–protein interaction networks were also established to identify critical genes. Results A total of 43 differentially expressed genes (DEGs) were identified, shared between endometriosis and RIF, with enrichment analysis highlighting pathways related to interleukin-6 signaling, FOXO-mediated transcription, smooth muscle contraction, and semaphorin interactions. Gene ontology studies revealed the significance of signal transduction and apoptosis regulation. ESR1, SOCS3, MYH11, CYP11A1, and CLU were identified as hub genes with potential as therapeutic targets and diagnostic indicators. Conclusion This study advances our understanding of the molecular framework underlying endometriosis and RIF. This presents potential possibilities for tailored treatment approaches and enhanced therapeutic results for individuals experiencing repeated or severe reproductive difficulties.
Hakimi et al. (Tue,) studied this question.
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