Robotic Prostheses and Neuromuscular Interfaces: A Review of Design and Technological Trends

Neuromuscular robotic prostheses have emerged as a critical convergence point between biomedical engineering, machine learning, and human–machine interfaces. This work provides a narrative state-of-the-art review regarding recent developments in robotic prosthetic technology, emphasizing sensor integration, actuator architectures, signal acquisition, and algorithmic strategies for intent decoding. Special focus is given to non-invasive biosignal modalities, particularly surface electromyography (sEMG), as well as invasive approaches involving direct neural interfacing. Recent developments in AI-driven signal processing, including deep learning and hybrid models for robust classification and regression of user intent, are also examined. Furthermore, the integration of real-time adaptive control systems with surgical techniques like Targeted Muscle Reinnervation (TMR) is evaluated for its role in enhancing proprioception and functional embodiment. Finally, this review highlights the growing importance of modular, open-source frameworks and additive manufacturing in accelerating prototyping and customization. Progress in this domain will depend on continued interdisciplinary research bridging artificial intelligence, neurophysiology, materials science, and real-time embedded systems to enable the next generation of intelligent prosthetic devices.