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September 10, 2025Open Access

The Essentials of Cell-Mediated Immunity Assays for the Management of CMV Infection after Solid Organ Transplantation

AGAlexis GuenetteNorthwestern University VSValentina StosorNorthwestern University

Key Points

Cell-mediated immunity assays can help manage CMV infection post-transplant, improving patient care.
These assays, alongside serological testing, enhance the prediction of cytomegalovirus development after transplantation.
The review evaluates current CMI assays for solid organ transplant recipients, noting benefits and challenges.
Incorporating CMV-specific immunoassays may lead to more tailored care plans for individuals post-transplant.

Abstract

Provided that cell-mediated immunity (CMI) is known to be vital in managing CMV infection post-transplant along with improving methods to predict the development of cytomegalovirus (CMV) following transplant, CMV-specific-cell-mediated immunoassays have been developed, commercially and research based, to be used in conjunction with pre-transplant CMV serological testing and prophylaxis to help tailor an individual care plan post-transplant. In this review, we assess the status of CMV CMI assays, and their potential uses in solid organ transplant recipients, including benefits and limitations.

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