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September 10, 2025

Protective Effect of Olive Leaves Extract on some physiological and biochemical parameters in Male Rats after the Administration of Paracetamol

Key Points

Olive leaf extract significantly mitigates paracetamol-induced liver and kidney parameters in rats.
Male rats treated with paracetamol showed increased liver enzymes, MDA, urea, and creatinine, contrasting with those given olive leaf extract.
Control and olive leaf extract groups exhibited significantly lower adverse effects compared to the paracetamol-treated group.
The findings suggest that olive leaf extract could enhance antioxidant levels and reduce toxicity following paracetamol exposure.

Abstract

This study aimed to know the protective effect of olive leaf extract against the side effects of Paracetamol in male rats such as liver & renal functions , antioxidant test (MDA, GSH) s in male rats. The study was conducted in the animal house of the Veterinary Medicine College, Tikrit University during the period (1. Desember.2023 to 30. December.2023). 24 adult male rats were used in this study. They were divided into three groups each group consists of 8 rats. These group are G1 (control), G2 (Paracetamol 1000mg/kg.B.W), G3(Paracetamol 1000mg/kg.B.W,+ Olive leaves extract 500mg/kg.B.W. Result of This study showed significantly increase (P≤0.05) in liver enzymes, MDA, Urea, creatinine and also a significant decrease in GSH parameter in G2 receiving (Paracetamol 1000mg/kg) after 30 days from treatment compared with control group but significantly graduated decreased (P≤0.05) in Paracetamol + olive leaf extract treated G3 due to protective effect of OLE .However after treatment with the Paracetamol +OLE group detected a significant increase (P≤0.05) in GSH parameter compared to Paracetamol group. Conclusion: The OLE has a significant protective effect from Paracetamol on some side effects in the hematological and biochemical parameters the male rats

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