Palladium-Catalyzed Carbonylative Synthesis of Amide-Containing 3,4-Dihydroisoquinolin-1(2H)-ones from N-Propargylamides

Key Points

• The reaction yields high amounts of amide-containing 3,4-dihydroisoquinolin-1(2H)-one derivatives efficiently.
• Using TFBen as a CO source enhances safety and convenience during the carbonylation process.
• The cyclization method employs amines to incorporate the amide unit into the target scaffold.
• These findings indicate potential for developing varied amide structures through this palladium-catalyzed approach.

Abstract