What type of study is this?

This is a Transcriptomic Meta-Analysis study.

September 10, 2025Open Access

Transcriptomic Meta‐Analysis Reveals Hub Genes Integrating Multiple Abiotic Stress Responses in Wheat

MDMinqiang DingYangtze University SFSajid FiazUniversity of Lahore KWKui WanMinistry of Public Security of the People's Republic of China

Key Points

Identification of 3237 differentially expressed genes (DEGs) shows wheat's response to multiple stresses.
Core transcription factors MYB, bHLH, and HSF are crucial for enhancing abiotic stress tolerance.
Phenotypic effects indicate significant changes in plant height, biomass, and chlorophyll content under stress conditions.
Upregulation of eight candidate genes suggests critical roles in wheat's adaptive mechanisms.

Abstract

ABSTRACT Climatic challenges increasingly threaten global food security, necessitating crops with enhanced multi‐stress resilience. Through systematic transcriptomic analysis of 100 wheat genotypes under heat, drought, cold, and salt stress, we identified 3237 differentially expressed genes (DEGs) enriched in key stress‐response pathways. Core transcription factors ( MYB , bHLH , HSF ) and two functional modules governing abiotic tolerance were characterized. Phenotypic assessments revealed significant stress‐induced alterations in plant height, biomass, and chlorophyll content. RT‐qPCR confirmed marked upregulation of eight candidate genes, including BES1 / BZR1 and GH14 , across most stresses, indicating their critical role in wheat's adaptive responses. This study aims to identify potential genes linked to multiple abiotic stress tolerance and provides an experimental foundation as well as theoretical support for the future development of stress‐resilient crops.

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