Assessment of C-reactive ProteinAlbumin Ratio (CAR), Calcium, and Parathyroid Hormone Levels among Sudanese Rheumatoid Arthritis Patients in White Nile State

Background: Rheumatoid arthritis (RA) is a long-lasting inflammatory condition characterized by inflammation of the synovial membrane in the joints and may lead to reduced mobility, joint deformities, and disability. The development of precise diagnostic tools remains a persistent challenge in the effective management of the disease, aiming to improve patient outcomes. The present study was conducted to assess the diagnostic values of serum biomarkers among rheumatoid patients. Materials and Methods: An analytical case-control study conducted at Kosti Teaching Hospital included 100 rheumatoid patients as the case group and 100 healthy individuals as controls. Blood samples were collected and analyzed for the C-reactive protein (CRP), rheumatoid factor (RF) erythrocyte sedimentation rate (ESR), C-reactive protein albumin ratio (CAR), Calcium, parathyroid hormone (PTH) and Albumin. Data was analyzed using SPSS version (27). Results: Our findings indicated that levels of RF, PTH, ESR, and CAR were significantly elevated in cases compared to controls, (PConclusion: Elevated levels of RF, ESR, CRP, CAR, and PTH have been linked to rheumatoid arthritis. Furthermore, CAR has the potential to serve as a cost-effective and readily implementable diagnostic biomarker for rheumatoid arthritis.