Efficacy of Padikara Parpam (Alum) with L-Ascorbic Acid Against Bacterial Pathogens

Drug-resistant bacteria and unidentified infectious pathogens continue to pose serious risks to public health. Both the demand for traditional medical systems to be readied for Siddha preparation and their scientific documentation are expanding. Siddha ancient literature contains numerous polyherbal formulations that are used to treat a wide range of illnesses. In Siddha therapy, certain mineral formulations are therapeutically utilized to cure or prevent infectious diseases in addition to herbal formulations. The purpose of the current study was to examine the antibacterial properties and therapeutic efficacy of Padikara Parpam, a siddha mineral preparation with L- ascorbic acid. The outcome of the phytochemical analysis suggests that the medicine that combines Padikara Parpam and L-Ascorbic acid exhibits very little phytochemical ingredients. The combined drug of Padikara Parpam and L- Ascorbic acid demonstrates the greatest amount of biochemical ingredients, according to the study's findings. The combination drug has a distinct peak at 248 nm in the absorbance of 1.917. The PPLAA was found to be potentially active against the majority of the test microbes. The maximum antibacterial activity exhibited by PPLAA at 100 mg/ml against P. aeruginosa (28.5±0.25 mm) followed by S. aureus (27.7±0.78 mm), S. pyogens (26.9±0.92 mm) and E. coli (24.6±0.65 mm). The MIC values ranged from 0.39 mg/mL to 200 mg/mL. The MIC value for the PP and LAA against E. faecalis, P. mirabilis, A. baumannii, and S. maltophilia was >200 mg/ml. The evidence of antibacterial action against bacteria suggests that the siddha drug might be used to produce medications with a broad spectrum of activity.