The relevance of this study is conditioned by the significant prevalence of chronic kidney disease in cats and the prominent role of calcium-phosphorus metabolism disorders in its progression and the development of complications, which requires further scientific attention to improve approaches to animal treatment. The purpose of this review was to summarise modern scientific data on the influence of calcium and phosphorus on the course of chronic kidney disease in cats and to formulate recommendations for nutritional support. A systematic approach was employed to search and analyse scientific literature for 2020-2025. The review analysed the results of modern studies on the diagnostics of chronic nephropathy in small carnivores, clinical recommendations, and expert opinions in the field of veterinary medicine. The study found that the excess phosphorus content in the diet of animals directly correlates with the acceleration of disease progression, the development of secondary hyperparathyroidism, soft tissue calcification, and deterioration of the functional state of the kidneys. At the same time, excessive decrease in phosphorus concentration can cause hypercalcemia, loss of appetite, vomiting, and other metabolic disorders. The optimal diet for animals with chronic kidney disease is a calcium to phosphorus ratio within the range of 1.1:11.5:1. The study considered role of modern biomarkers, such as symmetrical dimethylarginine and fibroblast growth factor-23, in the early diagnosis and monitoring of chronic kidney disease. The study also analysed the efficacy of dietary therapy, particularly the use of phosphate binders, active forms of vitamin D, probiotics, antioxidants, and agents for the correction of acid-base homeostasis. A review of the literature confirmed that efficacious nutritional management is a key factor in the control of chronic kidney disease. The findings obtained emphasised the significance of developing optimal dietary strategies that account for both the phosphorus level and the calcium to phosphorus ratio in the blood serum. This will inhibit the progression of the disease and improve the quality of life of cats with chronic kidney disease
Umanets et al. (Wed,) studied this question.