The worm-specific Argonaute WAGO-4 has been shown to be involved in epigenetic memory in C. elegans , however, its mode of action remains unclear. Here, we use a wago-4 deletion mutant to show that general changes to 22G-RNAs, the small RNA cofactor binding WAGO-4 , do not correlate with changes to mRNA levels. We also show that the function of WAGO-4 differs in L4 larvae and in adult worms, and, importantly, we show that mRNA misregulation caused by loss of WAGO-4 persists in wild-type offspring of deletion mutants for at least five generations.
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Ann‐Sophie Seistrup
René F. Ketting
Jan Schreier
Institute of Molecular Biology
European Molecular Biology Laboratory
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Seistrup et al. (Wed,) studied this question.
www.synapsesocial.com/papers/68d44f8331b076d99fa571ec — DOI: https://doi.org/10.17912/micropub.biology.001769
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