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This is a Literature Review study.

September 16, 2025Open Access

The role of extrachromosomal DNA in tumorigenesis and progression

Key Points

Extrachromosomal DNA significantly contributes to oncogene expression and genomic instability in tumors, leading to adverse outcomes.
The presence of extrachromosomal DNA is linked to the evolution of drug resistance and correlates with poor patient prognosis.
This review examines the structure and functions of extrachromosomal DNA, impacting our understanding of tumor biology.
Understanding extrachromosomal DNA's role in tumorigenesis may guide future research directions and treatment strategies.

Abstract

In tumors, extrachromosomal DNA (ecDNA) is an important driver of oncogene expression, genomic instability, the evolution of drug resistance, and poor patient prognosis. ecDNA is present in various tumors but is rarely found in normal cells. Here, we provide a detailed review of the structure, genetics, occurrence, outcomes, and functions of ecDNA, offering further reference for research on ecDNA.

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Cite this study

Ma et al. (Mon,) studied this question.

www.synapsesocial.com/papers/68d4538f31b076d99fa58e5b — DOI: https://doi.org/10.3389/fonc.2025.1665024

Authors

Xiaoyang Ma

Yong Xia

Chuan Wu

Journals

Frontiers in Oncology

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References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

The role of extrachromosomal DNA in tumorigenesis and progression

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

References and Citations

Citation Network

Connected Papers

Discussion