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This is a Quantitative Study study.

September 17, 2025

Differentiation of Confluent Hepatic Fibrosis and Mass Forming Intrahepatic Cholangiocarcinoma with Infltrative Tumor Margin on MR Imaging

JLJingjing LiuQingdao University of Science and Technology

Key Points

Key MRI features can accurately differentiate confluent fibrosis from mass forming intrahepatic cholangiocarcinoma, improving diagnostic outcomes.
The study identified specific imaging markers like hepatic capsular retraction and signal homogeneity that assist in diagnosis.
Evaluating MRI findings, such as nonenhancement during the arterial phase, facilitates distinguishing between the two conditions.
These findings highlight the importance of precise imaging in avoiding unnecessary biopsies and improving patient care.

Abstract

Motivation: There is a diagnostic challenge even for experienced radiologists for confluent fibrosis (CF) and mass forming intrahepatic cholangiocarcinoma with infltrative tumor margin (mICCITM) due to some similarities in imaging findings. Goal(s): We investigated the magnetic resonance imaging (MRI) features for CF and mICCITM. Approach: The imaging features on conventional MRI, dynamic contrast enhanced (DCE)-MRI and DWI were analyzed. Results: The MR features of the hepatic capsular retraction at the site of lesion, nonenhancement or nonrimenhancement in arterial phase, and delayed phase signal homogeneity can be useful for the diagnosis of CF, as they allow differentiation from mICCITM. Impact: The study detected several key MRI features for accurate diagnosis CF and differentiation from mICCITM, which may avoid unnecessary biopsies and overtreatment, and providing better patient care.

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