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September 17, 2025

Modeled and Model-Free DCE-MRI Parameters to Identify Solid Renal Mass Subtype in Patients Undergoing Surgical Management

Key Points

Model-free parameters effectively distinguish between malignant and benign solid renal masses.
Diagnostic performance of multiparametric models was evaluated, showing potential in categorizing SRM subtypes.
In total, 26 different DCE-MRI parameters were assessed across a cohort of 43 patients.
Model-free analysis offers improved characterization over modeled parameters in this specific application.

Abstract

Motivation: Dynamic contrast-enhanced MRI (DCE-MRI) offers a non-invasive method to assess perfusion in solid renal masses (SRM), potentially aiding in their characterization. Goal(s): This study evaluated the diagnostic performance of modeled and model-free DCE-MRI parameters for differentiating SRM subtypes. Approach: In a prospective, single-center study of 43 patients with SRMs, we assessed the performance of 26 modeled/model-free DCE-MRI parameters for SRM subtyping. Results: Model-free parameters demonstrated significant differences between malignant and benign SRMs, while modeled parameters did not. Multiparametric models incorporating ccLS demonstrated identified malignant vs benign, ccRCC vs. non-ccRCC vs and ccRCC vs other SRM with good diagnostic performance. Impact: Model-free parameters demonstrated significant differences between malignant and benign SRMs, while modeled parameters did not. Multiparametric models incorporating ccLS demonstrated identified malignant vs benign, ccRCC vs. non-ccRCC vs and ccRCC vs other SRM with good diagnostic performance.

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