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This is a Quantitative Study study.

September 17, 2025

Tissue Water Referencing with Proton Density in MRSI for Metabolic Mapping at 7T

AAAhmet AzgınMedical University of Vienna PLPhilipp LazenMedical University of Vienna BDBarbara DymerskaQueen Mary University of London

Key Points

Proton density-based water maps improved concentration estimates in magnetic resonance spectroscopic imaging (MRSI), enhancing metabolic mapping.
A comparison revealed only ~4% difference in metabolic estimates between the proton density-based method and the literature-driven approach.
The approach was validated in both healthy volunteers and a glioma patient, indicating its versatility for various brain conditions.
Quantitative proton density maps can provide reliable internal references for MRSI, supporting both research and clinical diagnostics.

Abstract

Motivation: In MRSI, obtaining concentration estimates is desirable to using metabolite ratios. We were limited due to segmentation. PD-based water maps can address this issue. Goal(s): To compare and validate metabolic imaging using PD-based approach, and compared against literature-driven strategy. Approach: Quantitative proton density maps are used to arrive at the water content for metabolic imaging at 7T, allowing concentration estimation based on internal water mapping with PDs. Results: A PD-based tissue referencing was successfully implemented and compared against a literature-driven approach in 13 volunteers and one tumor patient. Regional comparisons showed ~4% difference between, with values aligning with the previously established ranges Impact: Using quantitative proton density maps as an internal reference for MRSI enables to get concentration estimates from not only healthy brains, but also in pathological ones like brains with glioma.

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