What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Comparative Feasibility of Multimodal Imaging Indicators for Glymphatic Function in Hematological Diseases: Significant Age Effects

Key Points

Age significantly impacts DTI-ALPS index and choroid plexus volume in patients with hematological diseases, indicating the need for careful selection of imaging methods.
The study found that BOLD-CSF coupling has minimal correlation with age but positively correlates with hemoglobin levels, suggesting different age-related impacts on imaging indicators.
Multimodal neuroimaging techniques were employed alongside laboratory biomarkers to evaluate glymphatic function across varying ages in the patient population.
Careful consideration of age-related influences in imaging methods can improve the assessment of glymphatic function in participants from diverse age ranges.

Abstract

Motivation: At present, there are many imaging analysis methods to assess cerebral glymphatic function, but the reliability of these methods remains controversial. Goal(s): This study aims to compare the feasibility of different imaging indicators of glymphatic function in patients with hematological diseases. Approach: Multimodal neuroimaging (including DTI-ALPS, BOLD-CSF coupling, and choroid plexus volume) and laboratory biomarkers were used to evaluate glymphatic function in patients with hematological diseases. Results: DTI-ALPS index and choroid plexus (CP) volume were significantly influenced by age, while BOLD-CSF coupling showed minimal correlation with age and a positive correlation with hemoglobin (Hb) levels. Impact: Imaging methods for evaluating glymphatic function should be selected carefully, with special consideration of age-related influences on DTI-ALPS index and CP volume, particularly when samples involve a wide age range.

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