What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Non-contrast Time-SLIP Renal Perfusion Imaging using Stack-of-Stars with ASL

Key Points

The method provides an effective way to assess renal perfusion without using contrast agents, enhancing patient safety.
Renal perfusion quantification was successfully achieved, supporting its potential as a diagnostic tool.
The interleaved Stack-of-Stars acquisition significantly improved motion robustness compared to traditional methods.
The technique could provide a safer alternative for patients who cannot receive gadolinium-based contrast.

Abstract

Motivation: Kidney diseases require accurate perfusion quantification, but traditional imaging methods using contrast agents are unsuitable for some patients. A safe and motion robust non-contrast ASL technique is needed to assess renal perfusion. Goal(s): Develop and validate a non-contrast renal perfusion imaging method using an interleaved Stack-of-Stars acquisition scheme combined with Time-SLIP ASL and T2Prep modules. Approach: Implemented the sequence on a clinical 3T MRI scanner. Optimized imaging parameters through phantom studies. Conducted in-vivo scans to assess renal perfusion in multiple pulsed delays. Results: The technique successfully implemented and accessed renal perfusion quantification. Interleaved acquisition enhanced motion robustness, eliminating the need for respiratory gating. Impact: The proposed non-contrast imaging technique provides a safe and effective alternative for renal perfusion assessment, benefiting patients unsuitable for gadolinium-based contrast injection studies and potentially becoming an alternate tool for diagnosis.

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