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September 17, 2025

Comparison of CE-MRI, Non-contrast-enhanced MRV and Black Blood Imaging in the diagnosis of Cerebral Vein Thrombosis：A Meta-Analysis

HLHan LiNorthwestern Polytechnical University MHMingjia HouTongji Hospital YJYujia JiaoJiangxi Applied Engineering Vocational Institute

Key Points

Black Blood Imaging demonstrated an area under the curve of 1.00, significantly outperforming CE-MRI and NCE-MRV.
The area under the curve for CE-MRI was 0.93, which is comparable to NCE-MRV at 0.95, with no significant difference (P = 0.08).
A comprehensive literature review was conducted from January 2013 to August 2024 to assess diagnostic performance.
BBI may serve as a frontline tool in diagnosing CVT, emphasizing the need for improved accuracy in detection.

Abstract

Motivation: The early diagnosis of cerebral venous thrombosis (CVT), a rare disease with poor prognosis, currently poses a clinical challenge. Goal(s): To assess the accuracy of Black Blood Imaging (BBI), Contrast-enhanced MRI (CE-MRI) and Noncontrast-enhanced MR venography (NCE-MRV) in diagnosing CVT. Approach: A comprehensive review of literature from January 2013 to August 2024 was conducted and compare the diagnostic performance of BBI, CE-MRI and NCE-MRV. P< .05 indicates significant difference. Results: The area under the curve (AUC) for BBI was 1.00, significantly outperforming CE-MRI and NCE-MRV (P < .005). The AUC for CE-MRI achieved comparable results to NCE-MRV (0.93 vs. 0.95; P = 0.08). Impact: BBI exhibits the utmost accuracy in diagnosing CVT when compared to NCE-MRV and CE-MRI, poised to become a frontline diagnostic tool. While NCE-MRV surpasses CE-MRI in CVT detection sensitivity, it lags slightly in excluding non-CVT cases.

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