What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Multi-site use of a vendor-agnostic, open-source protocol (VOP) framework to validate and share open-source pulse sequences

Key Points

The framework successfully validated and shared open-source pulse sequences across multiple sites.
Quantitative MR measures for T1 and T2 were accurate and similar across different platforms.
Data were acquired from six sites on multiple MRI vendor platforms, enabling collaboration.
The initiative highlights the effectiveness of open-source protocols in enhancing reproducibility in MRI research.

Abstract

Motivation: A community-driven vendor-agnostic, open-source protocols (VOP) framework will expand the acquisition of reproducible MR data by collaboratively, safely, effectively, and ethically sharing magnetic resonance (MR) protocols. Goal(s): To validate and share two Pypulseq and GammaStar generated pulse sequences at multiple sites and two field strengths Approach: We acquired T1w, T2w, and quantitative relaxometric data from six sites on the Siemens, Philips, and the mri4all Zeugmatron1 platforms; sharing the code, data, images and documentation; compliant with the framework requisites Results: The sites fulfilled the requirements of the framework, and sites performing qMR provided similar and accurate T1 and T2 measures on the respective phantoms Impact: We demonstrated the expanded use of the VOP framework to validate and share the IRSE and TSE sequences across sites, vendors, software versions, and two field strengths. This framework created an online platform to interact and share pulse sequences.

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