What type of study is this?

This is a Quantitative Study study.

September 17, 2025

White matter axon effective radii a biomarker for acute mild TBI by a high B value Diffusion weighted imaging in a high performance head only scanner.

GKGail KohlsWalter Reed National Military Medical Center HYHaymanot Yalewayker HMH Douglas MorrisUniformed Services University of the Health Sciences

Key Points

Detecting changes in axon diameter using high B-value diffusion MRI shows promise for mild TBI diagnosis.
MAGNUS SE-DWI effectively tracks axon diameter changes over time in individual patients with mild TBI.
High B-value imaging enables observation of microstructural changes in white matter, impacting recovery monitoring.
This MRI approach could significantly benefit warfighters diagnosed with mild TBI, aiding in therapy evaluation.

Abstract

Motivation: Detect a mild traumatic brain injury with a reliable diagnostic for staging disease state and the testing therapies for treating the malady inacute and long term phase. Goal(s): ): Develop a MRI biomarker that can be repeated used on patients especially in the warfighter population which have more that 500,000 diagnosed mTBI over the past 30 year. Approach: Use of diffusion MRI to determine the white matter microstructural state namely the axon diameter. Results: MAGNUS SE-DWI high-B can detect changes in axon diameter and follow these changes in single subject over time. Impact: : High B-value diffusion imaging (b > 30000 mm2/sec) can detect changes in mild TBI subjects that can be seen to progress through the recoveryprocess. The high-performance gradient system, MAGNUS, (200mT/m, 500T/m/s) scanning without peripheral nerve stimulation in the subject.

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