What type of study is this?

This is a Experimental Study study.

September 17, 2025

Phase Reversed Interleaved Multi-Echo (PRIME) with phase, field map and motion navigators for highly accelerated distortion-free diffusion MRI

Key Points

PRIME achieves high-fidelity, distortion-free diffusion MRI with 490μm isotropic resolution, enhancing imaging precision.
Adding additional echoes during dead time improves data quality without increasing repetition time (TR).
The method incorporates field map estimation and motion correction effectively using gSlider RF encoding for better results.
This innovative sequence has potential implications for various applications requiring detailed diffusion imaging in clinical settings.

Abstract

Motivation: Current multi-shot diffusion MRI (dMRI) with gSlider RF encoding acquisition has a limited in-plane acceleration factor per shot and substantially long dead time. Goal(s): To develop a highly accelerated distortion-free dMRI sequence with high fidelity. Approach: We propose a highly accelerated distortion-free dMRI sequence, PRIME, which benefits from incorporating additional echoes for field map estimation, phase correction, and motion estimation without prolonging TR, especially when gSlider RF encoding is used. Results: PRIME enables high-fidelity distortion-free dMRI up to 490μm isotropic resolution with the benefit of adding additional echoes utilizing dead time in gSlider RF-encoded acquisitions. Impact: We propose a highly accelerated distortion-free dMRI sequence, which can achieve 490μm isotropic resolution with high-fidelity field maps, shot-to-shot phase, and motion correction from additional echoes without prolonging repetition time when gSlider RF encoding is used.

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