September 17, 2025

Combining Arterial Spin Labeling and Cardiovascular Indices in Children with Pulmonary Embolism

Key Points

ASL detected pulmonary perfusion defects in all studies performed within 4 weeks of diagnosis, ensuring accurate evaluations.
A significant inverse correlation between the perfusion defect and LV end-diastolic volume index supports the diagnostic potential of ASL.
Using sagittal ASL with MS-FAIR revealed critical insights into lung perfusion and its relationship with cardiac function.
The findings highlight ASL's role as a non-invasive technique for understanding cardiopulmonary interactions in pediatric patients.

Abstract

Motivation: Arterial spin labeling (ASL) is a non-contrast, free-breathing sequence that is recently used for assessing lung perfusion Goal(s): We assessed utility of ASL for detecting pulmonary perfusion defects and correlate perfusion defects with cardiac indices in children ≤ 18 years diagnosed with pulmonary embolism Approach: Sagittal ASL using MS-FAIR was used to detect pulmonary perfusion. CMR indices at rest and supine bike ergometry were analyzed and compared with perfusion defect. Results: Of the 27 studies, ASL detected perfusion defects in all 19 studies performed within 4 weeks of PE diagnosis. An inverse correlation between perfusion defect and LV end-diastolic volume index was found. Impact: ASL is a non-contrast, free breathing sequence that detects pulmonary perfusion defects in children with pulmonary embolism. An inverse correlation between perfusion defect and LV end-diastolic volume index was found, providing insights into cardiopulmonary interactions and potential therapeutics.

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