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This is a Experimental Study study.

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September 17, 2025

Bridging the gap: 150μm resolution whole brain ex-vivo imaging at 7T with RF shimming

Key Points

Ultra-high resolution MRI at 150μm reveals fine lesions and mesoscale structures effectively.
Using RF shimming, significant improvements in SNR were achieved during ex-vivo imaging.
Ex-vivo scans with enhanced SNR showcase the potential for detailed neuroradiological assessments.
Commercial hardware enabled efficient imaging, highlighting accessible methodologies for high-resolution studies.

Abstract

Motivation: To demonstrate that ultra-high resolution whole brain MRI acquired at ultra-high field (7T) can be used to acquire mesoscale voxel sizes in ex-vivo samples, using commercially available hardware. Goal(s): To evaluate the impact of RF-shimming methods on image quality in mesoscale MRI, and to acquire ex-vivo imaging with sufficient resolution and SNR to investigate mesoscale pathology. Approach: At 150μm isotropic resolution, RF shimming approaches were compared for their SNR and CoV. Subsequently, high-SNR ex-vivo scanning was achieved by averaging and denoising, and used for neuroradiological reading. Results: Ultra-high resolution MRI enabled the detection and delineation of fine lesions and mesoscale anatomical structures. Impact: Using commercial hardware and overnight scan times, ultra-high resolution MRI at 150μm isotropic voxel size can be acquired with sufficient SNR and image quality to detect and differentiate mesoscale structures

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