Motivation: Diffusion-weighted MR spectroscopy can be used to non-invasively assess lactate intracellular-extracellular compartmentation in the brain at equilibrium, but long measurement times may hamper detection of any transient changes. Goal(s): Detecting transient changes in lactate distribution would be invaluable to study lactate dynamics. Approach: We propose to use dMRS to non-invasively detect transient changes in lactate compartmentation induced by intravenous lactate infusion in the mouse brain. Results: we were able to capture transient changes in lactate concentration and distribution in the mouse brain with a time resolution of 6 minutes. Impact: We were able to non-invasively capture transient changes in intracellular-extracellular lactate distribution using dMRS, and it would be invaluable to estimate its vascular fraction and exchange kinetics between compartments to better understand lactate's role in brain function.
Malaquin et al. (Tue,) studied this question.
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