4D flow MRI of splanchnic vasculature for diagnosis of severe portal hypertension and prediction of outcomes

Motivation: Non-invasive detection of severe portal hypertension PH; hepatic venous pressure gradient (HVPG)≥12 mmHg is important to prevent decompensation and death in patients with chronic liver disease. Goal(s): We assess the diagnostic performance of hemodynamic parameters measured with 4D flow MRI in the splanchnic vasculature for diagnosis of severe PH and prediction of liver decompensation. Approach: In our prospective, single-center study, 56 patients with chronic liver disease had 4D flow MRI within a month of invasive HVPG measurement. Results: Splanchnic hemodynamic measurements by 4D flow MRI identified patients with severe portal hypertension with excellent diagnostic performance, and predicted liver decompensation with good diagnostic performance. Impact: 4D flow MRI diagnoses severe portal hypertension with excellent performance, and predicts hepatic decompensation with equivalent performance to HVPG, making it suitable for integration into surveillance MRI protocols for patients with liver cirrhosis.