What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Reproducibility of single-voxel PRESS-MRS for 2HG quantification in a custom-made phantom using vendor and non-clinical software.

Key Points

Reproducibility of 2HG measurements was tested using different scanner and coil combinations across sites, showing promising consistency.
Quantification techniques, including offline and vendor software analysis, yielded comparable results, with implications for clinical translation.
Single-voxel PRESS-MRS provides a non-invasive method to assess brain glioma mutational status, which can aid in diagnosis.
Study findings may enhance the standardization of MRS protocols in clinical settings for reliable metabolite quantification.

Abstract

Motivation: 2HG-MRS has potential to non-invasively determine mutational status of brain gliomas if integrated into clinical practice however a clinically accessible acquisition and analysis approach has not been fully established. Goal(s): Our goal is to assess reproducibility of metabolite measurements, including 2HG, in a custom-made phantom scanned across different scanners and sites, using a variety of coils. A secondary goal is to compare the quantification of metabolites using an offline analysis technique versus a vendor analysis software. Approach: We will perform single-voxel PRESS on a custom-made phantom across multiple scanner and coil combinations. Analysis performed with non-clinical and vendor software will be compared. Impact: This study will be of interest to those wanting to translate 2HG MRS to the clinic.

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