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This is a Quantitative Study study.

September 17, 2025

Diffusion Tensor Imaging as a Methodology for Optic Nerve Evaluation

KCKamri ClarkeAdvanced Imaging Research (United States)ZYZakia Ben YoussNYU Langone Health PFPatryk FilipiakNYU Langone Health

Key Points

Good reliability found with average ICC scores of 0.966 for fractional anisotropy and 0.970 for apparent diffusion coefficient.
Study highlights the importance of diffusion MRI in providing detailed optic nerve assessments for early treatment.
Non-invasive imaging techniques have the potential to improve diagnosis of optic neuropathies like glaucoma.
Assessments were conducted on 8 healthy subjects, ensuring reproducibility of diffusion tensor imaging metrics.

Abstract

Motivation: Current diffusion MRI (dMRI) diagnostic techniques for optic nerve (ON) neuropathies can assess general degeneration and acute damage. We aim to provide more detailed representation of the ON microstructure for earlier and more targeted treatment. Goal(s): Evaluate the reproducibility of ON Diffusion Tensor Imaging (DTI) metrics. Approach: Test/retest values of Fractional Anisotropy (FA) and Apparent Diffusion Coefficient (ADC) were measured along the ONs of 8 healthy subjects. Reproducibility was evaluated with the intraclass correlation coefficient (ICC). Results: We observed an average ICC score of 0.966 for FA and 0.970 for ADC at a 95% confidence interval, indicating good reliability. Impact: Non-invasive optic nerve screening with DTI may provide additional insight into the optic nerve microstructure making it a potential avenue to identify optic neuropathies, such as glaucoma.

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