What type of study is this?

This is a Experimental Study study.

September 17, 2025

Accelerated 3D mapping of whole brain venous oxygenation with nested-shift under sampling and ESPIRIT reconstruction

Key Points

3D TRU-VERA achieved reliable Yv measurements, enhancing detection of oxygenation changes.
Using nested-shift under-sampling with ESPIRIT, optimal accuracy was reached with high spatial resolution.
Validation against traditional 2D techniques confirmed the sensitivity of this approach to changes in venous oxygenation.
The method offers vessel-specific insights into regional cerebral oxygen metabolism, promising rapid assessments.

Abstract

Motivation: Non-invasive measurement of cerebral venous oxygenation (Yv) is essential, but existing method is limited to 2D due to technical difficulties, especially long scan duration. Goal(s): Developing a 3D T2-Relaxation-Under-Velocity-Encoding-and-Rapid-Acquisition (3D TRU-VERA) sequence for whole brain Yv quantification, including cortical and deep veins, while minimizing scan time. Approach: Optimized under-sampling schemes and reconstruction methods for accurate Yv quantification, validated with 2D techniques and tested for reproducibility and sensitivity to oxygenation change. Results: Nested-shift under-sampling with ESPIRIT provided optimal accuracy, achieved 1.04×1.04×2mm³ resolution in 7min23sec. 3D TRU-VERA demonstrated reliable Yv measurements, comparable to TRUST and TRUPC, and showing Yv reduction across veins post-caffeine. Impact: The 3D TRU-VERA sequence enables rapid, non-invasive assessment of venous oxygenation (Yv) across the entire brain, providing vessel-specific quantification and comprehensive evaluation of regional cerebral oxygen metabolism.

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