Motivation: Explore the contribution of individual factors to structural brain changes, and the cognitive outcomes that are associated with such changes. Goal(s): Study aimed to examine the effects of inflammatory risk factors on a myelin proxy, measured by the ratio of T1w and T2w images, as well as the interactions of these factors and myelin on cognition. Approach: We utilized 3 neuroimaging techniques, genetic sequencing, and cognitive assessment to study the links between myelin, IL-1β, iron deposits, and cognition in general linear models. Results: Myelin and iron interact to affect future executive function and memory performance across the lifespan. Impact: We demonstrated that non-invasive and widely available imaging techniques can predict cognitive outcomes several years later, and thus might provide clinically relevant targets for mitigating cognitive aging.
Gonen et al. (Tue,) studied this question.
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