What type of study is this?

This is a Experimental Study study.

September 17, 2025

Optimized Susceptibility Weighted Imaging for the Detection of Central Vein Sign in Multiple Sclerosis at 3-tesla

Key Points

Optimized susceptibility weighted imaging increased central vein sign detection by 23%, enhancing diagnostic accuracy.
Diagnostic classification improved, with 7 out of 10 MS patients classified as CVS-positive using the optimized protocol.
The study compared the optimized SWI protocol to standard SWI, demonstrating greater effectiveness in detecting the CVS.
The findings support the use of advanced imaging techniques for better diagnosis in multiple sclerosis patients.

Abstract

Motivation: Standard SWI results in isointense or hypointense appearance of brain lesions preventing adequate detection of the central vein sign (CVS). Goal(s): This study aims to evaluate an optimized SWI protocol for improved detection of CVS at 3T. Approach: An optimized SWI protocol was developed by reducing the flip angle (from 15° to 5°) to provide adequate image contrast for CVS detection and compared against standard SWI. Results: CVS detection was increased by 23% when using optimized SWI as compared to standard. Diagnostic classification was also improved using optimized SWI (7/10 MS-patients classified as CVS-positive) versus standard SWI (3/10 MS-patients classified as CVS-positive). Impact: Optimized SWI protocol increases CVS detection and improves diagnostic classification for MS as compared to standard SWI.

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