What type of study is this?

This is a Experimental Study study.

September 17, 2025

Feasibility of Velocity-Selective ASL MRA at 5T

Key Points

Velocity-selective ASL MRA is feasible at 5T, demonstrating decent image quality with selected modules.
Use of BIR-4 and BIR-8 modules achieved good results despite some subtraction errors in static tissues.
The study utilized innovative techniques like double-refocused hyperbolic-secant for better imaging outcomes.
Feasibility results support further exploration of ASL MRA techniques in ultra-high field settings.

Abstract

Motivation: Ultra-high field (UHF) provides improved SNR that benefits velocity-selective arterial spin labeling (VSASL) MRA; however, the sensitivity of VS prepulses to B0 and B1 inhomogeneities may render VS ASL MRA impractical. Goal(s): This study aims to assess the feasibility of VS ASL MRA for human brain at 5T. Approach: Double-refocused hyperbolic-secant (DRHS) module, B1-independent rotation (BIR)-4 module, and BIR-8 module based VS ASL MRA were implemented and compared at 5T. Results: The VS ASL MRA utilizing BIR-4 or BIR-8 modules at 5T had decent image quality, although there exist subtraction errors in static tissues. Impact: The study suggests that VS ASL MRA at 5T is feasible.

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